Veterinary Neuropathology

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Veterinary Neuropathology eBook Free Download

Veterinary Neuropathology eBook PDF Free Download

Edited by Marc Vandevelde, Robert J. Higgins and Anna Oevermann

Essentials of Theory and Practice

Published by Wiley Blackwell

About the Book

This Veterinary Neuropathology: Essentials of Theory and Practice is edited by Marc Vandevelde, Robert J. Higgins and Anna Oevermann. This First Edition introduces the theoretical and practical basics of veterinary neuropathology, this concise and well illustrated book is an essential basic diagnostic guide for pathologists, neurologists and diagnostic imaging specialists. It presents readers with strategies to deal with neuropathological problems, showing how to interpret gross and histological lesions using a systematic approach based on pattern recognition. It starts with an overview of the general principles of neuroanatomy, neuropathological techniques, basic tissue reaction patterns, and recognition of major lesion patterns. The book goes on to cover vascular diseases, inflammatory diseases, trauma, congenital malformations, metabolic-toxic diseases, neoplasia and degenerative diseases mainly of the central nervous system. In the respective chapters pathologists can quickly find information to support their daily diagnostic workup for both small and large domestic species. Based on the authors’ extensive diagnostic and post graduate teaching experience as well as the inclusion of MRI as it relates to neuropathology, this book also offers a comprehensive but basic analysis of veterinary neuropathology that neurologists and other MRI users will find very useful.

Features

An essential manual for daily diagnostic work
Richly illustrated with high quality colour gross, histological and MRI images
Includes a section on the function and use of MRI

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What You will Learn

The Topics Covered in this Textbook are

General neuropathology
Principles of neuroanatomy for diagnostic neuropathologists
Anatomical orientation by using the ventricular system
Major anatomical regions of interest
Histological neuroanatomy
Neuropathological techniques
Necropsy techniques
Brain sectioning, macroscopic inspection and sampling for histology
Basic tissue reaction patterns
Reactions of neurons to injury
Oligodendrocytes
Astrocytes
Microglia/macrophages
CSF spaces
Blood vessels
Disturbance of water balance: edema
Artifacts, postmortem degeneration, pseudolesions and old age
Recognizing major lesion patterns
The major lesion patterns
Lesion distribution pattern
Classifi cation of neurological diseases
General strategy
Neuropathology in the clinics: magnetic resonance imaging (MRI)
Basic MRI physics
Principles of interpretation
Neuropathology general
Neurology/functional neuroanatomy
Neuroanatomy
Techniques for PNS and muscle
Basic tissue reaction patterns
Edema
Artifacts, pseudolesions, old age
Magnetic resonance imaging

Vascular disorders
Pathophysiology of ischemia
General strategy for diagnosing vascular lesions
Common vascular lesions
General neuropathology
Principles of neuroanatomy for diagnostic neuropathologists
Anatomical orientation by using the ventricular system
Major anatomical regions of interest
Histological neuroanatomy
General neuropathology
Principles of neuroanatomy for diagnostic neuropathologists
Anatomical orientation by using the ventricular system
Major anatomical regions of interest
Histological neuroanatomy
Neuropathological techniques
Necropsy techniques
Brain sectioning, macroscopic inspection and sampling for histology
Basic tissue reaction patterns
Reactions of neurons to injury
Oligodendrocytes
Astrocytes
Microglia/macrophages
CSF spaces
Blood vessels
Disturbance of water balance: edema
Artifacts, postmortem degeneration, pseudolesions and old age
Recognizing major lesion patterns
The major lesion patterns
Lesion distribution pattern
Classifi cation of neurological diseases
General strategy
Neuropathology in the clinics: magnetic resonance imaging (MRI)
Basic MRI physics
Principles of interpretation
Neuropathology general
Neurology/functional neuroanatomy
Neuroanatomy
Techniques for PNS and muscle
Basic tissue reaction patterns
Edema
Artifacts, pseudolesions, old age
Magnetic resonance imaging

Vascular disorders
Pathophysiology of ischemia
General strategy for diagnosing vascular lesions
Common vascular lesions
Vascular lesions of the brain
Vascular lesions of the spinal cord
Ischemia in the peripheral nervous system and muscles
Cerebral infarcts
Hemorrhage
Hypertensive encehalopathy
Fibrocartilagenous emboli
Aortic thrombosis

Inflammatory diseases
Pathophysiology of inflammation
Entry and effect of infectious agents in the nervous system
Immune reaction of the host against the infectious agent in the CNS
Morphological aspects of the immune response
General strategy for diagnosis of inflammatory lesions
Recognizing major inflammatory reaction patterns
Determining the distribution pattern of the lesions
Specifi c features
Common CNS infections
Neurotropic viral infections
Viral granulomatous inflammation
Viral vasculitis
Viral leukoencephalitis
Bacterial infections
Mycotic and algal infections
Protozoal infections
Helminth infections
Non-infectious and immune-mediated inflammatory lesions
Neurological diseases assumed to be immune-mediated
Neurotropic viral infections
Viral granulomatous infections
Viral vasculitis
Demyelinating viral infections
Bacterial infections
Fungal infections
Protozoal infections
Helminth infections
Non-infectious and Immune-mediated inflammatory disorders

Trauma
Pathophysiology of CNS trauma
Pathogenesis of brain trauma 81
Pathogenesis of spinal cord trauma
General strategy for diagnosis of traumatic CNS lesions
Traumatic nervous system diseases
Trauma of the brain
Traumatic spinal cord lesions
Trauma in the peripheral nervous system
Pathophysiology of CNS trauma
Brain trauma
Intervertebral disc disease
Spinal malformations
Wobbler syndrome
Other causes of cord compression
Cauda equina syndrome

Congenital malformations
Pathophysiology
Ontogeny of the CNS
Etiology
General strategy for diagnosing anomalies of the CNS
Common malformations
Neural tube closure defects
Defects of forebrain induction
Neuronal migration disorders and sulcation defects
Disorders of proliferation or size
Encephaloclastic defects
Malformations in the caudal fossa and spinal cord
Congenital hydrocephalus and other anomalies of CSF pathways
Neural tube closure defects
Defects of forebrain induction
Neuronal migration disorders and sulcation defects
Encephaloclastic defects
Cerebellar hypoplasia
Dandy Walker syndrome
Chiari malformation, Syringomyelia
Hydrocephalus
Arachnoidal and ependymal cysts

Metabolic–toxic diseases
General strategy for diagnosis of metabolic–toxic lesions
The major patterns
Further differential diagnosis
Encephalomalacias/myelomalacias
Polioencephalomalacia (PE) or cerebrocortical necrosis (CCN)
Polioencephalomalacia of subcortical structures and brainstem
Poliomyelomalacia
Leukoencephalomalacias
Encephalomalacias involving both gray and white matter
Acquired metabolic–toxic selective lesions
Neuronal degeneration
Axonal degeneration
Myelin degeneration
Spongy degeneration
Metabolic–toxic lesions of the peripheral nervous system (PNS) and skeletal muscle
Metabolic–toxic neuropathies
Metabolic–toxic myopathies
Polioencephalomalacia large animals
Polioencephalomalacia in small animals
Hippocampal necrosis and sclerosis
Subcortical and brainstem encephalomalacias
Selenium poisoning
Equine leukomalacia
Enterotoxemia
CO poisoning
Metabolic toxic neuronal degenerations
Grass sickness
Acquired lysosomal storage diseases
Metabolic–toxic axonal degenerations
Irradiated feed-induced myelinopathy in cats
Toxic spongy degenerations
Hepatic encephalopathy
Toxic peripheral neuropathies
Metabolic peripheral neuropathies
Matabolic–toxic myopathies

Neoplasia
General strategy for diagnosis of neoplastic lesions
Clinic and diagnostic imaging
Interpretation of gross findings
Diagnosis
Grading
Tumors of neuroepithelial origin
Astrocytomas
Oligodendroglioma
Mixed gliomas (oligoastrocytomas)
Ependymoma
Choroid plexus tumors (papillomas and carcinomas)
Neuronal and mixed neuronal– glial tumors
Embryonal tumors
Tumors of cranial and spinal nerves
Benign PNST
Malignant peripheral nerve sheath tumors (MPNST)
Tumors of the meninges
Meningioma
Granular cell tumor
Mesenchymal tumors
Lymphomas and hematopoietic tumors
Primary T and B cell lymphomas
Intravascular lymphoma
Metastatic lymphoma
Primary CNS histiocytic sarcoma
Germ cell tumors
Germinoma
Teratoma
Embryonal tumors of nonneuroepithelial origin
Thoracolumbar spinal cord tumor (ectopic nephroblastoma)
Secondary or metastatic tumors
Glial tumors
Choroid plexus tumors
Neuronal tumors
Embryonal tumors
PNS tumors
Meningiomas
Granular cell tumor
Mesenchymal tumors
Lymphomas and hemapoetic tumors
Germ cell tumors
Nephroblastoma
Metastatic tumors

Degenerative diseases
General strategy for differential diagnosis of degenerative lesions
Recognizing the major pattern
Diagnosis
Degeneration of neurons
General aspects
Motor neuron diseases
Cerebellar degenerations
Other neuronal degenerations
Axonal degenerations
Wallerian-like degenerative axonopathies
Axonopathies with prominent axonal swelling
Myelin disorders
Leukodystrophies
Myelin dysgenesis
Storage diseases
Lysosomal storage diseases
Neuronal ceroid lipofucsinoses (NCL)
Lafora’s disease
Acquired lysosomal storage diseases
Spongiform encephalopathies
Transmissible degenerative diseases
Neuropathology of TSE
TSEs in domestic animals
Spongy degenerations
Defi nition and general morphological features
Spongy degeneration in branchedchain organic acidurias
Spongy degenerations of other causes
Selective symmetrical encephalomalacias (SSE)
General morphological features
Mitochondrial encephalopathies in people and similar lesions in animals
Degenerative diseases of the peripheral nervous system and muscle
Degenerative polyneuropathies
Degenerative myopathies
Further reading
Motor neuron diseases
Cerebellar degenerations
Other neuronal degenerations
Alzheimer disease
Wallerian-like axonal degenerations
Degenerative myelopathy in old dogs
Wallerian-like degeneration in large animals
Neuroaxonal dystrophy
Leukodystrophies
Dysmyelination
Lysosomal storage diseases
Spongiform encephalopathies
Spongy degenerations
Selective symmetrical encephalomalacias
Degenerative diseases of the PNS and muscles

For Whom is this Book For

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Details

Format of the eBook: PDF             Size: 85.7 MB

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