Stress, Trauma and Synaptic Plasticity

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Stress, Trauma and Synaptic Plasticity eBook Free Download

Stress, Trauma and Synaptic Plasticity eBook PDF Free Download

Edited by Maxwell Bennett and Jim Lagopoulos

Published by Springer

About the Book

This Stress, Trauma and Synaptic Plasticity is edited by Maxwell Bennett and Jim Lagopoulos. This First Edition presents the latest state of knowledge on grey matter changes in the brain following stress and trauma. Where do these changes take place and what are the underlying molecular mechanisms? These questions are addressed in several sections, providing detailed insights into the cellular and molecular alterations that occur in the brain after stress and trauma. The changes to the grey matter in certain areas of the brain are similar in stressed humans and animals, with the most likely basis for these changes being the degeneration of synaptic connections. In the book’s first sections the reader will learn about the core network of synaptic connections that are affected by stress and trauma disorders. These synaptic connections are modulated by dopamine, serotonin and Brain Derived Neurotrophic Factor (BDNF). In subsequent chapters, the NMDA-receptor mediated plasticity of these synapses is discussed, with particular attention given to how glucocorticoids can interfere with the function of BDNF and thereby affect the synapse’s physical stability. Furthermore, the reader will learn about the importance of the genetics of the glucocorticoid gene and the epigenetic control of BDNF in connection with synaptic plasticity. The authors conclude by integrating the observations summarized in the previous sections so as to present plausible hypotheses regarding the identity of the networks, synapses and molecular pathways that support fear and extinction. Providing an up-to-date overview of the mechanisms of synaptic plasticity and physiological changes in the stressed and traumatized brain, this book will appeal to researchers, clinicians and students in the neurosciences.

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What You will Learn

The Topics Covered in this Textbook are

Grey Matter Changes in the Brain Following Stress and Trauma
Synaptic Changes Responsible for Grey Matter Changes in the Brain of Animal Models Following Stress
Identification of the Core Neural Network Subserving PTSD in Animal Models and Their Modulation
Modulation of the Core Neural Network in Stress: The Role of Brain-Derived Neurotrophic Factor and LTP
Modulation of the Core Neural Network in Stress: The Role of Endocannabinoids and LTD
Functioning of the Core Neural Network in Fear and Extinction
Modulation of the Core Synaptic Network in Extinction: The Role of Brain-Derived Neurotrophic Factor

For Whom is this Book For

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Details

Format of the eBook: PDF     Size: 5.6 MB

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