Proteasome Inhibitors in Cancer Therapy

Proteasome Inhibitors in Cancer Therapy PDF eBook Free Download

Proteasome Inhibitors in Cancer Therapy eBook PDF Free Download

Edited by Julian Adams

Cancer Drug Discovery and Development

Published by Humana Press

About the Book

This Proteasome Inhibitors in Cancer Therapy is edited by Julian Adams. A panel of leading academic and pharmaceutical investigators takes stock of the remarkable work that has been accomplished to date with proteasome inhibitors in cancer, and examines emerging therapeutic possibilities and presented them in this First Edition textbook of Proteasome Inhibitors in Cancer Therapy.


– The topics range from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of current clinical trials underway.
– The discussion of rationales for testing proteasome inhibitors in cancer models covers the role of the proteasome in NF-kB activation, the combining of conventional chemotherapy and radiation with proteasome inhibition, notably PS-341, new proteasome methods of inhibiting viral maturation, and the role of protesome inhibition in the treatment of AIDS.
– The authors also document the development of bortezomib (Velcade) in Phase I clinical trials and in a multicentered Phase II clinical trials in patients with relapsed and refractory myeloma.

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What You will Learn

The Topics Covered in this Textbook are

Cancer Drug Development: Challenges in a Competitive Market
Introduction to the Proteasome and Its Inhibitors: Biochemistry and Cell Biology
Structures of the Yeast Proteasome Core Particle in Complex with Inhibitors
Natural Product and Synthetic Proteasome Inhibitors
Other Proteasome Inhibitors
The Proteasome in Cell-Cycle Regulation
Proteasome Inhibition and Apoptosis
The Proteasome and the COMPARE Algorithm
The Proteasome in Cancer Biology and Therapy
Radiosensitization and Proteasome Inhibition
Proteasome-Dependent Regulation of NF-aB Activation: Molecular Targeting of Chemotherapy Resistance
Bortezomib with Taxanes
Proteasome Inhibitor Therapy in a Brain Tumor Model
Anthracyclines and Bortezomib
TNF-Related Apoptosis-Inducing Ligand (TRAIL): Combination with Proteasome Inhibition For Anticancer Therapy?
Rationale for Combining the Proteasome Inhibitor Bortezomib with Cisplatin
The Effects of the HIV-1 Protease Inhibitor Ritonavir on Proteasome Activity and Antigen Presentation
Function(s) of the Ubiquitin–Proteasome System in Retrovirus Budding
Preclinical Development of Bortezomib (VELCADE): Rationale for Clinical Studies
Phase I Trials: Bortezomib Alone and in Combination With Standard Chemotherapies
Clinical Molecular Diagnostics for Proteasome Inhibitors in Cancer Therapy
Phase II Trials of Bortezomib for the Treatment of Multiple Myeloma

For Whom is this Book For

This 1st Edition textbook of Proteasome Inhibitors in Cancer Therapy: Cancer Drug Discovery and Development is perfect for Oncologists and Researchers. It is the must have reference for practitioners and residents! It acts as Reference Material for those MBBS students who are pursuing their Graduation in Oncology. It includes topics pretty useful for other Health Care Professionals including Clinical Pharmacists, Nurses and Professors.


Format of the eBook: PDF    Size: 7 MB


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Proteasome Inhibitors in Cancer Therapy eBook Free Download

Proteasome Inhibitors in Cancer Therapy PDF Free Download