Nanoparticles and Brain Tumor Treatment

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Nanoparticles and Brain Tumor Treatment eBook Free Download

Nanoparticles and Brain Tumor Treatment eBook PDF Free Download

Edited by Gerardo Caruso, Maria Caffo, Giuseppe Raudino and Francesco Tomasello

Published by ASME/Momentum Press

About the Book

This Nanoparticles and Brain Tumor Treatment is edited by Gerardo Caruso, Maria Caffo, Giuseppe Raudino and Francesco Tomasello. This – Edition despite progresses in surgery, radiotherapy, and in chemotherapy, an effective curative treatment of gliomas does not yet exist. Mortality is still close to 100% and the average survival of patients with GBM is less than 1 year. The efficacy of current anti-cancer strategies in brain tumors is limited by the lack of specific therapies against malignant cells. Besides, the delivery of the drugs to brain tumors is limited by the presence of the blood brain barrier. The oncogenesis of gliomas is characterized by several biological processes and genetic alterations, involved in the neoplastic transformation. The modulation of gene expression to more levels, such as DNA, mRNA, proteins and transduction signal pathways, may be the most effective modality to down-regulate or silence some specific gene functions. Gliomas are characterized by extensive microvascular proliferation and a higher degree of vasculature. In malignant gliomas targeted therapies efficacy is low.

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What You will Learn

The Topics Covered in this Textbook are

Introduction
Glioma biology
Invasion and angiogenesis
Blood-brain barrier
Blood-brain barrier physiology
Blood-brain barrier transport systems
Nanomedicine and nanotechnology
Nanoparticle drug delivery
Nanoparticle distribution
Nanoparticle functionalization
Nanoparticle targeting
Nanomedicine and cancer
Nanomedicine and toxicity
Nanoparticle technologies
Polymeric and polymer-drug conjugate nanoparticles
Micelle nanoparticles
Liposomes
Gold and silver nanoparticles
Metal oxide
Magnetic nanoparticles
Carbon nanotubes
Fullerenes
Peptides nanoparticles
Silica nanoparticles
Quantum dots
Dendrimers
Nanomedicine applications in brain tumors
Brain tumor drug targeting
Systemic approaches
Physiological approaches
Receptor-mediated transcytosis
Adsorptive-mediated transcytosis
Efflux pump inhibition
Cell-mediated drug transport
Direct CNS approaches
Intracerebral routes
Drug modifications and prodrugs
Experimental studies
Conclusions

For Whom is this Book For

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Details

Format of the eBook: PDF      Size: 760 KB

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