Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia

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Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia eBook Free Download

Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia eBook PDF Free Download

Edited by Masahiro Kizaki

Published by Springer

About the Book

This Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia is edited by Masahiro Kizaki. This First Edition provides a comprehensive understanding of the recent molecular genetics of Chronic Myelogenous Leukemia (CML) and a characterization of the molecular targets for drug development. Included are therapeutic implications, diagnosis, and prognosis for understanding and facilitating daily practice in the management of patients with CML. Understanding of the pathogenesis and therapy of hematological malignancies such as CML has grown significantly in recent years. This development owe much to the progress in molecular biology and now makes a major contribution to diagnosis and to treatment that pharmacologically targets the molecular events of CML. Molecular targeting therapy with newly developed agents such as small molecules and antibodies for hematological malignancies are being discovered after years of research. Some of these, including tyrosine kinase inhibitors such as imatinib, nilotinib, and dasatinib, lead to increased survival rates and improved therapies. With the opinion leaders of basic and clinical research in the field as authors, this book reviews recent advances in the biology of CML.

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What You will Learn

The Topics Covered in this Textbook are

Identification and Biology of CML Stem Cells
Molecular Mechanisms of CML Stem Cell Maintenance
Roles for Signaling Molecules in the Growth and Survival of CML Cells
Goals of CML Treatment in the Tyrosine Kinase Inhibitor Era
Biomarkers for Determining the Prognosis of CML
Updated European LeukemiaNet Recommendations for the Management of CML
Optimal Monitoring of CML Treatment: Molecular and Mutation Analysis
Recommendations for the Management of CML in the Era of Second-Generation TKIs
The Role of New TKIs and Combinations with Interferon-α for the Treatment of CML
Safety Profiles of First-Line TKIs and Managing Adverse Effects
Molecular Mechanism of TKI Resistance and Potential Approaches to Overcome Resistance
Discontinuation of Therapy and Treatment-Free Remission in CML

For Whom is this Book For

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Details

Format of the eBook: EPUB              Size: 2 MB

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Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia eBook Free Download

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