Pharmacokinetics in Drug Development Volume 3 eBook PDF Free Download
Advances and Applications
Edited by Peter L. Bonate and Danny R. Howard
Published by Springer
About the Book
This Pharmacokinetics in Drug Development, Volume 3 : Advances and Applications is edited By Peter L. Bonate and Danny R. Howard. In this Third Volume topics are selected on current development or technological issues facing drug development project teams. They regard the practical considerations for assessment of selected special development populations. For example, they include characterization of drug disposition in pregnant subjects, for measuring arrhythmic potential, for analysis tumor growth modeling, and for disease progression modeling.
Provides practical guidance on the application of pharmacokinetics as a drug development science
Includes characterization of drug disposition in pregnant subjects, for measuring arrhythmic potential, for analysis tumor growth modeling, and for disease progression modeling
Introduces important technologies like whole body autoradiography, digital imaging and dried blood spot sample collection methods are introduced, as both have begun to take a more visible role in pharmacokinetic departments throughout the industry.
Practical considerations for metabolite safety testing, transporter assessments, Phase 0 testing, and development and execution of drug interaction programs reflect current regulatory topics meant to address enhancement of both safety assessment and early decision-making during new candidate selection.
What You will Learn
The Topics Covered in this Textbook are
Modeling Tumor Growth in Oncology
Drug–Drug Interactions: Designing Development Programs and Appropriate Product Labeling
Modeling the Progression of Disease
The Use of Dried Blood Spots for Concentration Assessment in Pharmacokinetic Evaluations
Microdosing: Pharmacokinetic and Metabolism Data Early in the Drug Development Process
Metabolite Testing in Drug Development
The -Omics in Drug Development
Optimal Design of Pharmacokinetic–Pharmacodynamic Studies
Pharmacokinetic Studies in Pregnant Women
Design, Conduct and Analysis of Thorough QT Studies
Contribution of Quantitative Whole-Body Autoradioluminography to the Early Selection and Development of Drug Candidates
Pharmacokinetics, Modeling, and Simulation in the Development of Sunitinib Malate: A Case Study
The Clinical Significance of Drug Transporters in Drug Disposition and Drug Interactions.
For Whom is this Book For
The Information placed in this Pharmacokinetics in Drug Development, Volume 3 : Advances and Applications is essential for Pharmacists and for those Students who are pursuing their Graduation in Pharmacy.
Format of the eBook: PDF Size: 5.3MB
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