Critical Care Nephrology, 3rd Edition

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Critical Care Nephrology, 3rd Edition eBook Free Download

Critical Care Nephrology 3rd Edition eBook PDF Free Download

Edited by Ronco, Bellomo, Kellum and Ricci

Published by Elsevier

About the Book

This Critical Care Nephrology, 3rd Edition is edited by Ronco, Bellomo, Kellum and Ricci. This Third Edition provides authoritative coverage of the latest advances in critical care procedures for patients with renal diseases or disorders. Using common guidelines and standardized approaches to critically ill patients, this multidisciplinary reference facilitates better communication among all physicians who care for critically ill patients suffering from kidney disease, electrolyte and metabolic imbalances, poisoning, severe sepsis, major organ dysfunction, and other pathological events.


Offers detailed discussions of different forms of organ support, artificial organs, infections, acute illness occurring in chronic hemodialysis patients, and much more.
Places a special emphasis on therapeutic interventions and treatment procedures for a hands on clinical reference tool.
Presents information clearly, in a format designed for easy reference – from basic sciences to clinical syndromes to diagnostic tools.
Covers special populations such as children, diabetic patients, and the elderly.
An exceptional resource for nephrologists, intensivists, surgeons, or critical care physicians – anyone who treats critically ill renal patients.

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What You will Learn

The Topics Covered in this Textbook are

Section 1 Principles of Critical Care
The Critically ill patient
The Pathophysiological Foundations of critical care
Pulmonary support in the critically ill
Hemodynamic support in the critically ill patient
Monitoring of organ function in critical care
Kidney-Specific Severity Scores

Section 2 Principles of Renal Physiology
Practical Considerations of Renal Biopsies in Critical Care Patients
Tubular physiology
Glomerular Filtration Rate, Renal Functional Reserve and Kidney Stress Testing
Renal energy consumption and metabolism

Section 3 Epidemiology of AKI in critical care
Acute Kidney Injury: from clinical to molecular diagnosis
Community and hospital acquired Acute Kidney Injury
Epidemiology of Acute Kidney Injury in critically ill patients
AKI in patients with CKD

Section 4 Exposures and patient susceptibility
Genetic predisposition to AKI
Risks Factors and Risk Assessment in Acute Kidney Injury
Experimental Models of Acute Kidney Injury

Section 5 Humoral and cellular mechanisms of kidney damage
Renal blood flow and perfusion pressure
Humoral mediators in sepsis
Cell Death Pathways: Apoptosis and Regulated Necrosis
Pathogen Associated Molecular Patterns (PAMPs), Damage Associated Molecular Patterns (DAMPs), and their receptors in Acute Kidney Injury

Section 6 Clinical course of AKI and Biomarkers
AKI continuum: the conceptual model of AKD
Acute Kidney Disease, Renal Recovery and Post AKI Care
The role of biomarkers in AKI diagnosis and management
Functional biomarkers
Damage biomarkers
Stress biomarkers

Section 7 Mechanisms of repair or progression
The process of repair after AKI
Maladaptive repair and progression to CKD
Biomarkers of recovery and/or repair following Acute Kidney Injury

Section 8 Renal Histopathology in AKI
Renal Biopsy in AKI
Localization of injury and repair pathways

Section 9 Imaging techniques in Critical Care Nephrology
Ultrasonography and Doppler techniques
Contrast enhanced renal ultrasound
Radionuclide diagnostic techniques

Section 10 Clinical Syndromes and AKI
Multiple organ dysfunction syndrome
AKI in Burns and Trauma
Drug-Induced Acute Kidney Injury
Acute Kidney Injury in PregnancyAcute
AKI in oncology and tumour lysis syndrome
AKI in cardiac surgery
AKI in major surgery
Acute Kidney Injury in Heart Failure
AKI in kidney transplantation
Acute glomerulonephritis
Contrast-induced Acute Kidney Injury
Abnominal compartment syndrome

Section 11 Prevention and Treatment: General Treatment Concepts
Non-pharmacological prevention of AKI
Novel Drugs for AKI
Remote Ischemic Preconditioning

Section 12 Fluid and Electrolytes
Blood Biochemistry: Measuring Major Plasma Electrolytes
Assessment of Urine biochemistry
Disorders of Sodium and Water Balance
Disorders of Potassium and Magnesium
Calcium and Phosphate Physiology
Principles of Fluid Therapy
Blood and Blood Products
Loop and thiazide Diuretics
Vaptans and the treatment of hyponatremia
Aldosterone antagonists and other potassium sparing diuretics

Section 13 Acid-Base
Laboratory tests: blood gases, anion gap, stron ion gap
Acid Base physiology and diagnosis of disorders
Metabolic Acidosis
Hyperlactatemia and lactic acidosis
Renal Tubular Acidosis(RTA)
Metabolic alkalosis
Respiratory acid-base disorders
Iatrogenic and poison-derived acid base disorders

Section 14 Metabolism and nutrition in critical illness and AKI
Energy requirement and consumption in the Critically Ill Patient
Metabolic aspects of RRT
Aminoacid turnover, Protein metabolism and Nitrogen balance in Acute Kidney Injury
Carbohydrates and Lipids
Endocrinology of stress response to critical illness
Anemia of critical illness
Management of Nutrition in AKI and RRT
Blood Glucose Control in Critical Care
Enteral Nutrition

Section 15 Infectious diseases and Sepsis
Microbiological Considerations in the Intensive Care Patient
Innate Immunity and the Kidney
Adaptive immunity and Critical Illness
Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome
Tropical Infections Causing Acute Kidney Injury
The Sepsis Syndrome and septic shock
Complement and its Consequences in Sepsis
Coagulation abnormalities in sepsis
Endothelial dysfunction in sepsis
The kidney in sepsis and Mechanisms of AKI
Recommendation for sepsis management
Antibiotic Prescription in ICU and AKI
Renal Replacement Therapy in Septic AKI
Blood purification therapies for sepsis
Management of infection in patients with kidney transplant
Viral infections in the ICU
Management of antibiotic-resistant infections

Section 16 Acute Intoxication and Poisoning
Characteristics, Pathophysiology, and Effects of Common Toxic Substances
Drugs and Antidotes in Acute Intoxication and Laboratory Testing in Toxicology
Extracorporeal therapies in Acute Intoxication and Poisoning
Plasmapheresis in Acute Intoxication and Poisoning
Poisoning: Kinetics to Therapeutics

Section 17 AKI and Organ crosstalk
Bleeding and hemostasis in AKI
Gastrointestinal Complications of Acute Kidney Injury
Cardiovascular problems in AKI
Water and electrolyte disorders in AKI
Neurological problems in AKI
Immunological and infectious complications of AKI
Cellular response to AKI

Section 18 The heart and the kidney
Heart kidney crosstalk
Cardiorenal Syndrome Classification
Cardiorenal Syndrome type 1
Cardiorenal Syndrome type 2
Cardiorenal Syndrome type 3
Cardiorenal Syndrome type 4
Renal Function during Cardiac Mechanical Support and the Artificial Heart
The kidney in diastolic dysfunction
Principles of Volume Management in Congestive Hear Failure and Cardiorenal Syndrome
Management of overhydration in heart failure patients
Recent advances for stroke prevention in patients with atrial fibrillation and advanced kidney disease

Section 19 The lung and the kidney
Lung-kidney crosstalk
The Kidney during Mechanical Ventilation
ECMO and renal function
Extracorporeal CO2 removal
ECMO and CRRT in adult and children
Pulmonary Renal Syndromes

Section 20 The Liver and the Kidney
Liver-Kidney Interaction
Pathophysiology & management of the Hepatorenal Syndrome
Kidney Dysfunction after Liver Transplantation
Extracorporeal Liver Support and the Kidney

Section 21 The Brain and the Kidney
Treatment of Combined AKI and Cerebral Edema
Renal Protection in the Organ Donor
Effect of Extracorporeal Therapies on the Brain

Section 22 Fluid balance and its management in the critically ill
Components of fluid balance and monitoring
Methods of estimation of fluid status
The five B approach to fluid management
Mechanical fluid removal

Section 23 General principles of Acute renal replacement therapy
Indications for Renal Replacement Therapy in the Critically Ill
Principles of Extracorporeal Circulation and mass separation
Membranes and Filters for Use in Acute Renal Failure
Evolution of Machines for Acute Renal Replacement Therapy
Principles of Anticoagulation in Extracorporeal Circuits
Dialysis solutions and replacement fluids
Starting and Stopping Renal Replacement Therapy in the Critically Ill
The Concept of Renal Replacement Therapy Dose and Efficiency
Quantification of Acute Renal Replacement Therapy
Principles of Pharmacodynamics and Pharmacokinetics of Drugs Used in Extracorporeal Therapies
Ethical Considerations in Acute Renal Replacement Therapy

Section 24 Intermittent renal replacement therapies (IRRT)
Intermittent Techniques for Acute Dialysis
Solute and water transport in hemodialyzers, flow distribution and crossfiltration
Biocompatibility of the Dialysis System
Composition of Hemodialysis Fluids
Indications for and Contraindications to Intermittent Hemodialysis in Critically Ill Patients
Technical and Clinical Complications of Intermittent Hemodialysis in the Intensive Care Unit
Correction of Water, Electrolyte, and Acid-Base Derangements by Hemodialysis and Derived Techniques
Urea Kinetics, Efficiency, and Adequacy of Hemodialysis and Other Intermittent Treatments
Assessment of Fluid Status and Body Composition and Control of Fluid Balance with Intermittent Hemodialysis in the Critically Ill Patient
Outcome of Intermittent Dialysis in Critically Ill Patients with Acute Renal Failure
Hybrid Dialysis Techniques in the Intensive Care Unit
Plasma exchange in acute illness
Cascade filtration for ABO incompatible transplant
Nursing Issues and Procedures in acute dialysis

Section 25 Continuous Renal replacement therapies (CRRT)
Indications for CRRT: renal replacement versus renal support
Beginning and Ending CRRT in the Intensive Care Unit
Solute and Water Kinetics in Continuous Therapies
CRRT: modalities and their selection
Vascular access for renal replacement therapy in AKI patients
Anticoagulation Strategies for CRRT and citrate
Nursing Strategies to Prevent Coagulation in CRRT
Adequacy of CRRT: Precription and delivery
High-Volume Hemofiltration in the Intensive Care Unit
Pulse High-Volume Hemofiltration in Management of Critically Ill Patients with Sepsis or Septic Shock
High cut off membranes for mediators removal
Clinical Effects of Continuous Renal Replacement Therapies
Antibiotic adjustment in CRRT
Nomenclature: Basic principles
Nomenclature: Techniques

Section 26 Peritoneal Dialysis in critical illness
Peritoneal Dialysis in the Intensive Care Unit
Indications, Contraindications, and Complications of Peritoneal Dialysis in Acute Renal Failure
Solute and Water Transport across the Peritoneal Membrane
Choice of Peritoneal Dialysis Technique: Intermittent or Continuous
Correction of Fluid, Electrolyte, and Acid-Base Derangements by Peritoneal Dialysis in Acute Kidney Injury
Efficiency and Adequacy of Peritoneal Dialysis in Acute Renal Failure
Clinical Results and Complications of Peritoneal Dialysis in Acute Renal Failure
Treatment of Peritonitis and Other Clinical Complications of Peritoneal Dialysis in the Critically Ill Patient
Comparison of Peritoneal Dialysis with Other Treatments for Acute Renal Failure
Techniques and technology of Continuous-Flow Peritoneal Dialysis as Acute Therapy
Nursing Issues and Procedures in Acute Peritoneal Dialysis

Section 27 Extracorporeal Blood Purification Techniques beyond Dialysis
Sorbents and Hemoperfusion techniques
Therapeutic apheresis in critically ill patients: indicatins, modalities and techniques, clinical results.
MARS and extracorporeal liver support
Coupled Plasmafiltration-Adsorption
The Prometheus System
Toraymyxin and Other Endotoxin Adsorption Systems
The Plasmafiltration-Adsorption-Dialysis System
Extracorporeal membrane oxigenation for cardiac support
Extracorporeal membrane oxygenation for pulmonary support
Cell Based Therapies

Section 28 Critical Care Nephrology in Pediatrics
Pathophysiology of Pediatric Acute Kidney Injury
Epidemiology of Pediatric Acute Kidney Injury
Treatment of Acute Kidney Injury in Children: Conservative Management to Renal Replacement Therapy
Technical Aspects of Pediatric Continuous Renal Replacement Therapy
Multiple Organ Dysfunction in the Pediatric Intensive Care Unit
Drug Dosing in Pediatric Acute Kidney Insufficiency and Renal Replacement Therapy
Nutrition of Critically Ill Children with Acute Renal Failure
Continuous Renal Replacement Therapies in Combination with Other Extracorporeal Therapies
Outcome of Pediatric Acute Kidney Injury
Renal Replacement Therapy for the Critically Ill Infant
Inborn Errors of Metabolism and Continuous Renal Replacement Therapy
Modified Ultrafiltration in Pediatric Heart Surgery
Techniques and machines for Pediatric RRT
Antibiotics in critically ill newborns and children: nephrotoxicity and management during RRT

Section 29 Kidney Transplantation
Patient Selection and Pretransplantation Care for Kidney Transplant Recipients
Kidney Support and Perioperative Care in Kidney Transplantation
AKI in Kidney Transplant Recipients

Section 30 Special Kidney Problems in the Intensive Care Unit
Management of CKD and ESKD patients in the ICU
Management of AKI in Patients with Diabetes in the Intensive Care Unit
Diagnosis and Management of AKI in the Emergency Room
Anticancer Drugs and the Kidney
Anti-inflammatory Drugs and the Kidney
Calcineurin Inhibitors and Other Immunosuppressive Drugs and the Kidney
Alternative Medicine and Chinese Herbs and the Kidney
Environment, Smoking, Obesity, and the Kidney
Lead and Heavy Metals and the Kidney
Statins and the Kidney
Erythropoietin Therapy in Critically Ill Patients and AKI
Vasoactive Drugs and Renal Function
End points for clinical trials in AKI
Hypothermia and the kidney

For Whom is this Book For



Format of the eBook: PDF      Size: 47.2 MB


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