Clinical Pharmacokinetics, 6th Edition

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Clinical Pharmacokinetics, 6th Edition eBook Free Download

Clinical Pharmacokinetics 6th Edition eBook PDF Free Download

Edited by John E. Murphy

Published by American Society of Health-System Pharmacists

About the Book

This Clinical Pharmacokinetics, 6th Edition is edited by John E. Murphy. This Sixth Edition textbook includes the most current information, covering issues such as rational use of drug concentration measurements, changes in dosing obese patients, and considerations for a wider variety of drugs for special populations.

Features

– This book has a new chapter focused on pharmacogenomics and its impact on pharmacokinetic parameters, as well as discussion of pharmacogenomics throughout the book.
– The new edition includes everything you need to know about pharmacokinetics today Drugs, dosing, and therapeutic Drug concentration measurements.
– Includes New chapter on the impact of pharmacogenomics.
– Provides Info on Neonatal, pediatric, obese, and geriatric dosing. Dosing in renal disease and creatinine clearance estimation. Drugs sorted by family and as single drugs.
– Written in a straightforward style, with numerous charts and lists, the sixth edition makes complicated dosing and monitoring information easy to find and understand.
– Whether you are a student or practitioner, it is a resource you will turn to for reliable guidance throughout your pharmacy career.

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What You will Learn

The Topics Covered in this Textbook are

Introduction: General Pharmacokinetic Principles.

SECTION 1: BASIC CONCEPTS AND SPECIAL POPULATIONS

1.Rational Use of Drug Concentration Measurements
Evaluating the Need for a Drug Concentration Measurement
Approaches to Dosing with Limited Need for Drug Concentration Measurements
Conclusion

2. Estimating Creatinine Clearance
Factors Affecting Estimates of Glomerular Filtration Rate
Creatinine Assay Standardization
Formulas to Estimate Creatinine Clearance in Adults
Body Weight
Low Serum Creatinine in Elderly or Underweight Patients
Amputations
Spinal Cord Injury
Chronic Renal Insufficiency
Dialysis
Liver Disease
Pediatrics
Patients with Unstable Renal Function
Estimating Time to Steady State Serum Creatinine Concentration
Creatinine Clearance Estimation in Unstable Renal Function

3. Renal Drug Dosing Concepts
Clinical Assessment of Kidney Function
Mechanisms of Drug Clearance
Nonrenal Mechanisms
Volume of Distribution
Drug Dosing Strategies for CKD Patients
Hemodialysis and Continuous Renal Replacement Therapy
Conclusion

4. Medication Dosing in Overweight and Obese Patients
Obtaining an Accurate Weight
Body Composition Changes Associated with Obesity
Size Descriptors
Pharmacokinetic Considerations
Oral Absorption
Concept of Dose Proportionality
Recommendations for Dosing Medications in Obese Patients
Genetic and Genomic Considerations

5. The Role of the Pharmacogenomics in Pharmacokinetics
Introduction
Basic Definitions
History of Pharmacogenetics and Pharmacogenomics
Cytochrome P450 Enzymes and Solute Carrier Transmembrane Proteins
Impact of the Blood-Brain Barrier
Special Populations
Pharmacogenomics Examples in Therapeutics
Summary

6.Drug Dosing in Pediatric Patients
General Pharmacokinetic Information
Distribution
Elimination
Metabolism
Factors Influencing Drug Disposition
Pharmacogenomics in Children

7. Therapeutic Drug Monitoring in the Geriatric Patient
Physiologic Changes
Drug Elimination
Age-Related Pharmacodynamic Changes Influencing Drug Response
Summary of Changes

SECTION 2: SPECIFIC DRUGS AND DRUG CLASSES

8. Aminoglycosides
Usual Dosage Range in Absence of Clearance-Altering Factors
Dosage Form Availability
General Pharmacokinetic Information
Dosing Strategies
Therapeutic Ranges
Therapeutic Monitoring
Pharmacodynamic Monitoring
Drug–Drug Interactions
Drug–Disease State or Condition Interactions
Pharmacogenomic Implications of Aminoglycoside Use

9. Antidepressants
Usual Dosage Range in Absence of Clearance-Altering Factors
Dosage Form Availability
General Pharmacokinetic Information
Dosing Strategies
Therapeutic Range
Therapeutic Monitoring
Further Considerations for Sampling
Pharmacodynamic Monitoring
Drug–Disease State or Condition Interactions

10. Antiepileptics
Felbamate
Gabapentin
Lamotrigine
Tiagabine
Topiramate
Levetiracetam
Oxcarbazepine
Zonisamide
Pregabalin
Lacosamide
Rufinamide
Vigabatrin
Ezogabine
Clobazam
Perampanel
Eslicarbazepine
Use of the Newer Antiepileptic Drugs
Generic Substitution of AEDs

11. Antirejection Agents
Usual Dosage Range in Absence of Clearance-Altering Factors
Dosage Form Availability
General Pharmacokinetic Information
Therapeutic Range
Therapeutic Monitoring
Pharmacodynamic Monitoring
Drug–Drug Interactions
Drug–Gene Interactions
Molecular Weights for Unit Conversions

12. Carbamazepine
Usual Dosage Range in Absence of Clearance-Altering Factors
General Pharmacokinetic Information
Dosing Strategies
Therapeutic Range
Therapeutic Monitoring
Pharmacodynamic Monitoring
Drug–Drug Interactions
Drug–Disease State or Condition Interactions

13. Digoxin
Usual Dosage Range in Absence of Clearance-Altering Factors
Dosing Strategies
Therapeutic Monitoring
Pharmacodynamic Monitoring
Drug–Drug Interactions
Drug–Disease/Condition Interactions

14. Ethosuximide
Usual Dosage Range in Absence of Clearance-Altering Factors
General Pharmacokinetic Information
Dosing Strategies
Therapeutic Range
Therapeutic Monitoring
Pharmacodynamic Monitoring
Drug–Drug Interactions
Drug–Disease State or Condition Interactions
15. Unfractionated Heparin, Low Molecular Weight Heparin, and Fondaparinux
Unfractionated Heparin
UFH: Usual Dosage Range in Absence of Clearance-Altering Factors
UFH: Dosage Form Availability
UFH: General Pharmacokinetic Information
UFH: Dosing Strategies
UFH: Therapeutic Range
UFH: Therapeutic Monitoring
UFH: Pharmacodynamic Monitoring—Concentration-Related Efficacy
UFH: Pharmacodynamic Monitoring—Concentration-Related Toxicity
Reversing Heparin’s Effect
UFH: Drug–Drug Interactions
UFH: Drug–Disease State or Condition Reactions
Low Molecular Weight Heparins
LMWH: Usual Dosage Range in Absence of Clearance-Altering Factors
LMWH: Dosage Form Availability
LMWH: General Pharmacokinetic Information
LMWH: Dosing Strategies
LMWH: Therapeutic Range
LMWH: Therapeutic Monitoring
LMWH: Assay Issues
LMWH: Pharmacodynamic Monitoring—Concentration-Related Efficacy
LMWH: Pharmacodynamic Monitoring—Concentration-Related Toxicity
LMWH: Reversing the Effect of LMWHS
LMWH: Drug–Drug Interactions
LMWH: Drug–Disease State or Condition Interaction
Fondaparinux
Fondaparinux: Dosage Range

16. Lidocaine
Usual Dosage Range in Absence of Clearance-Altering Factors
Dosage Form Availability
General Pharmacokinetic Information
Clearance
Half-Life and Time to Steady State
Dosing Strategies
Therapeutic Range
Pharmacodynamic Monitoring: Concentration-Related Efficacy and Toxicity
Drug–Drug Interactions
Drug–Disease State or Condition Interactions

17. Lithium
Usual Dosage Range in Absence of Clearance-Altering Factors
Dosage Form Availability
General Pharmacokinetic Information
Therapeutic Range
Therapeutic Monitoring
Pharmacodynamic Monitoring
Drug–Drug Interactions
Drug–Disease State Interactions and Special Populations

18. Phenobarbital
Usual Dosage Range in Absence of Clearance-Altering Factors
General Pharmacokinetic Information
Half-Life and Time to Steady State
Therapeutic Range
Drug Monitoring Assay Considerations
Suggested Sampling Times and Effect on Therapeutic Range
Pharmacodynamic Monitoring—Concentration-Related Efficacy
Pharmacodynamic Monitoring—Concentration-Related Toxicity
Drug–Drug Interactions
Drug–Disease State or Condition Interactions

19. Phenytoin and Fosphenytoin
Usual Dosage Range in Absence of Clearance-Altering Factors
Dosage Form Availability
General Pharmacokinetic Information
Therapeutic Range
Therapeutic Monitoring
Pharmacodynamic Monitoring
Drug–Drug Interactions
Drug–Disease State or Condition Interactions

20. Theophylline
Usual Dosage Range in Absence of Clearance-Altering Factors
Dosage Form Availability
General Pharmacokinetic Information
Dosing Strategies
Therapeutic Range
Therapeutic Monitoring
Pharmacodynamic Monitoring
Drug–Drug Interactions
Drug–Disease State or Condition Interactions

21. Valproate
Usual Dosage Range in Absence of Clearance-Altering Factors
General Pharmacokinetic Information
Dosing Strategies
Dosage Adjustment
Therapeutic Range
Effect of Age and Pregnancy on Therapeutic Range
Therapeutic Monitoring
Initial and Follow-Up Monitoring
Pharmacodynamic Monitoring—Concentration-Related Efficacy
Drug–Drug Interactions
Drug–Disease State or Condition Interactions

22. Vancomycin
Usual Dosage Range in Absence of Clearance-Altering Factors
Dosage Form Availability
General Pharmacokinetic Information
Dosing Strategies
Therapeutic Range
Therapeutic Drug Monitoring
Pharmacodynamic Monitoring
Drug–Drug Interactions
Drug–Disease State Interactions
Assay Issues

23. Warfarin
Usual Dosage Range in Absence of Clearance-Altering Factors
Dosage Form Availability
General Pharmacokinetic Information
Therapeutic Range
Therapeutic Monitoring
Pharmacodynamic Monitoring
Drug–Drug Interactions
Drug–Disease State or Condition Interactions

For Whom is this Book For

This Clinical Pharmacokinetics, 6th Edition is perfect for Pharmacy Students and Pharmacists. It acts as Reference Material for those students those who are pursuing their Graduation in Pharmacy. It includes topics pretty useful for Other Health Care Professionals including Clinical Pharmacists, Nurses and Professors.

Details

Format of the eBook: PDF      Size: 6 MB

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