Chemical Biology of Nucleic Acids

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Chemical Biology of Nucleic Acids eBook Free Download

Chemical Biology of Nucleic Acids eBook PDF Free Download

Edited by Volker A. Erdmann, Wojciech T. Markiewicz and Jan Barciszewski

Fundamentals and Clinical Applications

Published by Springer

About the Book

This Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications is edited by Volker A. Erdmann, Wojciech T. Markiewicz and Jan Barciszewski. This First Edition discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.

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What You will Learn

The Topics Covered in this Textbook are

RNA as Major Components in Chemical Evolvable Systems
How the Early Genetic Code Was Established?: Inference from the Analysis of Extant Animal Mitochondrial Decoding Systems
Isomerization of RNA Phosphodiester Linkages
Effects of Ionic Liquid and Liposomes on the Structure, Stability, and Function of Nucleic Acids
Oxidative Damage on RNA Nucleobases
Use of FRET to Study Dynamics of DNA Replication
Design, Characterization, and Application of Imidazopyridopyrimidine:Naphthyridine Base-Pairing Motifs Consisting of Four Hydrogen Bonds
Creation of Unnatural Base Pair Systems Toward New DNA/RNA Biotechnologies
Flexible Nucleobase Analogues: Novel Tools for Exploring Nucleic Acids
Sequence-Selective Recognition of Double-Stranded RNA
Determining Transient Nucleic Acid Structures by NMR
Diastereomer-Specific Repertoire of 7′R- or 7′S-Me-Carba-Locked Nucleic Acids (cLNAs) in Antisense Oligo/RNA Duplexes and Engineering of Physico-chemical and Enzymological Properties
Challenges and Opportunities for Oligonucleotide-Based Therapeutics by Antisense and RNA Interference Mechanisms
Progress in Chemically Modified Nucleic Acid Aptamers
Aptamers as Molecular Smugglers
Biochemical Aspects of Subcellular RNA Transport and Localization
Small Size, Big Impact: Bacterial Functional Nucleic Acids and Their Applications
Towards Defined DNA and RNA Delivery Vehicles Using Nucleic Acid Nanotechnology
Targeted Editing of Therapeutic Genes Using DNA-Based Transcriptional Activators: Scope and Challenges
Interaction of DNA Intramolecular Structures with Their Complementary Strands: A Thermodynamic Approach for the Control of Gene Expression
Site-Directed Spin Labeling of RNA for Distance Measurements by EPR
Chemo-enzymatic Strategies to Modify RNA in vitro or in Living Cells
Metal Dependence of Ligand Binding and Heavy-Atom Derivatization of Evolutionarily Distinct PreQ1 Riboswitches
DNA G-Quadruplexes and I-Motifs in Therapeutics and Diagnostics
Peptides Targeting G-Quadruplex Structures
Synthesis of Site-Specifically Modified Long-mer RNAs
Synthesis and Exon-Skipping Activity of Chemically Modified RNAs
mRNA and snRNA Cap Analogs: Synthesis and Applications
Innovative Chemistry for Synthesis of Regular RNA, 5′-Triphosphate RNA, or 5′-Capped RNA

For Whom is this Book For

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Details

Format of the eBook: PDF       Size: 16.7 MB

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Chemical Biology of Nucleic Acids eBook Free Download

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