Analysis of Complex Diseases

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Analysis of Complex Diseases eBook Free Download

Analysis of Complex Diseases eBook PDF Free Download

Edited by Guanyu Wang

A Mathematical Perspective

Published by CRC Press

About the Book

This Analysis of Complex Diseases: A Mathematical Perspective is edited by Guanyu Wang. This First Edition involves many etiological and risk factors operating at multiple levels—molecular, cellular, organismal, and environmental. The incidence of such diseases as cancer, obesity, and diabetes are increasing in occurrence, urging us to think fundamentally and use a broader perspective to identify their connection and revolutionize treatments. The understanding of biological data derived from studying diseases can be enhanced by theories and mathematical models, which clarify the big picture and help to reveal the overarching mechanisms that govern complex biological phenomena. Focusing on diseases related to cellular energy metabolism, such as cancer and diabetes, Analysis of Complex Diseases: A Mathematical Perspective presents a holistic approach for illuminating the molecular mechanisms of these diseases and the evolutionary underpinning of their simultaneous epidemics. Using mathematics to identify patterns of deviation from normality, or the healthy state—spanning multiple levels from molecules to the organism—the author identifies a range of dynamical behaviors that correspond to either cellular physiology or pathology. He uses the information from multiple levels in order to develop a unified theory, which includes the discovery that certain diseases may stem from well-evolved, useful mechanisms activated in the wrong context. This book is divided into three parts. Part I focuses on the organismal level to describe normal physiology and how the body as a whole meets its functional requirements. Part II addresses the subcellular, molecular level to elucidate the organizing principles of cellular biomolecules to meet the demands of the organism. Part III examines complex diseases by combining information from the organismal level and the molecular level, offering a paradigm that can be extended to the study of other categories of diseases.

Features

Presents a unique global perspective studying multiple related diseases as mathematical entities, revealing their mechanistic connections
Follows the mathematical spirit, not just mathematical modeling, to study diseases
Considers multiple levels: evolutionary, organismal, and molecular
Focuses on the defining pandemics of the current generation, including cancer, diabetes, and obesity
Includes examples of successful mathematical analyses of diseases
Contains professional illustrations

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What You will Learn

The Topics Covered in this Textbook are

Part I Organismal Level: What Is Required

Food Intake and Energy Metabolism
Glucose Homeostasis
Optimal Glucose Homeostasis
Bistability as a Fundamental Phenomenon

Part II Molecular Level: What Can Be Provided?

Molecular Biology
Biomolecular Network
PI3K-AKT-TOR Pathway

Part III Mathematical Analysis of Complex Diseases

Diseases Related to Metabolism
Mathematical Modeling of the PI3K-AKT-TOR Pathway
Fundamental Decomposition
Normal Phenotype
Disease Phenotypes
Tao of Diseases

For Whom is this Book For

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Details

Format of the eBook: PDF      Size: 5.2 MB

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Analysis of Complex Diseases eBook Free Download

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